A hybrid strain is created by cross-breeding two or more cannabis strains.  Hybrid may refer to indica and sativa crosses, crosses of two or more sativas, two or more indicas and other variations.  Due to their bred genetics,hybrids can offer a desired profile of benefits, often elevating desirable effects while minimizing less-desirable effects depending on personal preference.  Hybrids are used to help manage the symptoms of various health conditions.